PCOS

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PCOS Webinar Materials

References (Click to Open)

Ainehchi, N., Khaki, A., Farshbaf-Khalili, A., Hammadeh, M., & Ouladsahebmadarek, E. (2019). The Effectiveness of Herbal Mixture Supplements with and without Clomiphene Citrate in Comparison to Clomiphene Citrate on Serum Antioxidants and Glycemic Biomarkers in Women with Polycystic Ovary Syndrome Willing to Be Pregnant: A Randomized Clinical Trial. Biomolecules, 9(6). https://doi.org/10.3390/biom9060215

Akdoğan, M., Tamer, M. N., Cüre, E., Cüre, M. C., Köroğlu, B. K., & Delibaş, N. (2007). Effect of spearmint (Mentha spicata Labiatae) teas on androgen levels in women with hirsutism. Phytotherapy Research: PTR, 21(5), 444–447. https://doi.org/10.1002/ptr.2074

Arentz, S., Abbott, J. A., Smith, C. A., & Bensoussan, A. (2014). Herbal medicine for the management of polycystic ovary syndrome (PCOS) and associated oligo/amenorrhoea and hyperandrogenism; a review of the laboratory evidence for effects with corroborative clinical findings. BMC Complementary and Alternative Medicine, 14, 511. https://doi.org/10.1186/1472-6882-14-511

Arentz, S., Smith, C. A., Abbott, J., & Bensoussan, A. (2017). Nutritional supplements and herbal medicines for women with polycystic ovary syndrome; a systematic review and meta-analysis. BMC Complementary and Alternative Medicine, 17(1), 500. https://doi.org/10.1186/s12906-017-2011-x

Arentz, S., Smith, C. A., Abbott, J., Fahey, P., Cheema, B. S., & Bensoussan, A. (2017). Combined Lifestyle and Herbal Medicine in Overweight Women with Polycystic Ovary Syndrome (PCOS): A Randomized Controlled Trial. Phytotherapy Research, 31(9), 1330–1340. https://doi.org/10.1002/ptr.5858

Bailey, C. J. (2017). Metformin: Historical overview. Diabetologia, 60(9), 1566–1576. https://doi.org/10.1007/s00125-017-4318-z

Barrea, L., Arnone, A., Annunziata, G., Muscogiuri, G., Laudisio, D., Salzano, C., Pugliese, G., Colao, A., & Savastano, S. (2019). Adherence to the Mediterranean Diet, Dietary Patterns and Body Composition in Women with Polycystic Ovary Syndrome (PCOS). Nutrients, 11(10). https://doi.org/10.3390/nu11102278

Benelli, E., Del Ghianda, S., Di Cosmo, C., & Tonacchera, M. (2016). A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. International Journal of Endocrinology, 2016, 3204083. https://doi.org/10.1155/2016/3204083

Bevilacqua, A., Carlomagno, G., Gerli, S., Montanino Oliva, M., Devroey, P., Lanzone, A., Soulange, C., Facchinetti, F., Carlo Di Renzo, G., Bizzarri, M., Hod, M., Cavalli, P., D’Anna, R., Benvenga, S., Chiu, T. T., & Kamenov, Z. A. (2015). Results from the International Consensus Conference on myo-inositol and D-chiro-inositol in Obstetrics and Gynecology—Assisted reproduction technology. Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology, 31(6), 441–446. https://doi.org/10.3109/09513590.2015.1006616

Ciampelli, M., Fulghesu, A. M., Cucinelli, F., Pavone, V., Ronsisvalle, E., Guido, M., Caruso, A., & Lanzone, A. (1999). Impact of insulin and body mass index on metabolic and endocrine variables in polycystic ovary syndrome. Metabolism: Clinical and Experimental, 48(2), 167–172.

Cozzolino, M., Vitagliano, A., Pellegrini, L., Chiurazzi, M., Andriasani, A., Ambrosini, G., & Garrido, N. (2020). Therapy with probiotics and synbiotics for polycystic ovarian syndrome: A systematic review and meta-analysis. European Journal of Nutrition. https://doi.org/10.1007/s00394-020-02233-0

Delcour, C., Robin, G., Young, J., & Dewailly, D. (2019). PCOS and Hyperprolactinemia: What do we know in 2019? Clinical Medicine Insights. Reproductive Health, 13. https://doi.org/10.1177/1179558119871921

Dumesic, D. A., Oberfield, S. E., Stener-Victorin, E., Marshall, J. C., Laven, J. S., & Legro, R. S. (2015). Scientific Statement on the Diagnostic Criteria, Epidemiology, Pathophysiology, and Molecular Genetics of Polycystic Ovary Syndrome. Endocrine Reviews, 36(5), 487–525. https://doi.org/10.1210/er.2015-1018

Foretz, M., Guigas, B., & Viollet, B. (2019). Understanding the glucoregulatory mechanisms of metformin in type 2 diabetes mellitus. Nature Reviews. Endocrinology, 15(10), 569–589. https://doi.org/10.1038/s41574-019-0242-2

Garg, D., & Merhi, Z. (2015). Advanced Glycation End Products: Link between Diet and Ovulatory Dysfunction in PCOS? Nutrients, 7(12), 10129–10144. https://doi.org/10.3390/nu7125524

Grant, P. (2010). Spearmint herbal tea has significant anti-androgen effects in polycystic ovarian syndrome. A randomized controlled trial. Phytotherapy Research: PTR, 24(2), 186–188. https://doi.org/10.1002/ptr.2900

Heimark, D., McAllister, J., & Larner, J. (2014). Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Endocrine Journal, 61(2), 111–117.

Hewlett, M., Chow, E., Aschengrau, A., & Mahalingaiah, S. (2017). Prenatal Exposure to Endocrine Disruptors. Reproductive Sciences, 24(1), 19–27. https://doi.org/10.1177/1933719116654992

Heydarpour, F., Hemati, N., Hadi, A., Moradi, S., Mohammadi, E., & Farzaei, M. H. (2020). Effects of cinnamon on controlling metabolic parameters of polycystic ovary syndrome: A systematic review and meta-analysis. Journal of Ethnopharmacology, 254, 112741. https://doi.org/10.1016/j.jep.2020.112741

Højlund, K. (2014). Metabolism and insulin signaling in common metabolic disorders and inherited insulin resistance. Danish Medical Journal, 61(7), B4890.

Isabella, R., & Raffone, E. (2012). Does ovary need D-chiro-inositol? Journal of Ovarian Research, 5(1), 14. https://doi.org/10.1186/1757-2215-5-14

Kamel, H. H. (2013). Role of phyto-oestrogens in ovulation induction in women with polycystic ovarian syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 168(1), 60–63. https://doi.org/10.1016/j.ejogrb.2012.12.025

Kancherla, V., Garn, J. V., Zakai, N. A., Williamson, R. S., Cashion, W. T., Odewole, O., Judd, S. E., & Oakley, G. P. (2016). Multivitamin Use and Serum Vitamin B12 Concentrations in Older-Adult Metformin Users in REGARDS, 2003-2007. PloS One, 11(8), e0160802. https://doi.org/10.1371/journal.pone.0160802

Kazemi, M., McBreairty, L. E., Chizen, D. R., Pierson, R. A., Chilibeck, P. D., & Zello, G. A. (2018). A Comparison of a Pulse-Based Diet and the Therapeutic Lifestyle Changes Diet in Combination with Exercise and Health Counselling on the Cardio-Metabolic Risk Profile in Women with Polycystic Ovary Syndrome: A Randomized Controlled Trial. Nutrients, 10(10). https://doi.org/10.3390/nu10101387

Kempegowda, P., Melson, E., Manolopoulos, K. N., Arlt, W., & O’Reilly, M. W. (2020). Implicating androgen excess in propagating metabolic disease in polycystic ovary syndrome. Therapeutic Advances in Endocrinology and Metabolism, 11, 2042018820934319. https://doi.org/10.1177/2042018820934319

Laganà, A. S., Rossetti, P., Buscema, M., La Vignera, S., Condorelli, R. A., Gullo, G., Granese, R., & Triolo, O. (2016). Metabolism and Ovarian Function in PCOS Women: A Therapeutic Approach with Inositols. International Journal of Endocrinology, 2016. https://doi.org/10.1155/2016/6306410

Lansdown, A., & Rees, D. A. (2012). The sympathetic nervous system in polycystic ovary syndrome: A novel therapeutic target? Clinical Endocrinology, 77(6), 791–801. https://doi.org/10.1111/cen.12003

Lim, S. S., Davies, M. J., Norman, R. J., & Moran, L. J. (2012). Overweight, obesity and central obesity in women with polycystic ovary syndrome: A systematic review and meta-analysis. Human Reproduction Update, 18(6), 618–637. https://doi.org/10.1093/humupd/dms030

Lim, Siew S., Hutchison, S. K., Van Ryswyk, E., Norman, R. J., Teede, H. J., & Moran, L. J. (2019). Lifestyle changes in women with polycystic ovary syndrome. The Cochrane Database of Systematic Reviews, 3, CD007506. https://doi.org/10.1002/14651858.CD007506.pub4

Liu, Q., Li, S., Quan, H., & Li, J. (2014). Vitamin B12 status in metformin treated patients: Systematic review. PloS One, 9(6), e100379. https://doi.org/10.1371/journal.pone.0100379

Machado, V., Escalda, C., Proença, L., Mendes, J. J., & Botelho, J. (2020). Is There a Bidirectional Association between Polycystic Ovarian Syndrome and Periodontitis? A Systematic Review and Meta-analysis. Journal of Clinical Medicine, 9(6). https://doi.org/10.3390/jcm9061961

McCreight, L. J., Bailey, C. J., & Pearson, E. R. (2016). Metformin and the gastrointestinal tract. Diabetologia, 59(3), 426–435. https://doi.org/10.1007/s00125-015-3844-9

Moini Jazani, A., Nasimi Doost Azgomi, H., Nasimi Doost Azgomi, A., & Nasimi Doost Azgomi, R. (2019). A comprehensive review of clinical studies with herbal medicine on polycystic ovary syndrome (PCOS). Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 27(2), 863–877. https://doi.org/10.1007/s40199-019-00312-0

Pani, A., Gironi, I., Di Vieste, G., Mion, E., Bertuzzi, F., & Pintaudi, B. (2020). From Prediabetes to Type 2 Diabetes Mellitus in Women with Polycystic Ovary Syndrome: Lifestyle and Pharmacological Management. International Journal of Endocrinology, 2020, 6276187. https://doi.org/10.1155/2020/6276187

Patel, R., & Shah, G. (2017). Effect of metformin on clinical, metabolic and endocrine outcomes in women with polycystic ovary syndrome: A meta-analysis of randomized controlled trials. Current Medical Research and Opinion, 33(9), 1545–1557. https://doi.org/10.1080/03007995.2017.1279597

Puttabyatappa, M., Cardoso, R. C., & Padmanabhan, V. (2016). Effect of maternal PCOS and PCOS-like phenotype on the offspring’s health. Molecular and Cellular Endocrinology, 435, 29–39. https://doi.org/10.1016/j.mce.2015.11.030

Romitti, M., Fabris, V. C., Ziegelmann, P. K., Maia, A. L., & Spritzer, P. M. (2018). Association between PCOS and autoimmune thyroid disease: A systematic review and meta-analysis. Endocrine Connections, 7(11), 1158–1167. https://doi.org/10.1530/EC-18-0309

Rosenfield, R. L., & Ehrmann, D. A. (2016). The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The Hypothesis of PCOS as Functional Ovarian Hyperandrogenism Revisited. Endocrine Reviews, 37(5), 467–520. https://doi.org/10.1210/er.2015-1104

Rotterdam ESHRE/ASRM-Sponsored PCOS consensus workshop group. (2004). Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Human Reproduction (Oxford, England), 19(1), 41–47.

Sam, S., & Ehrmann, D. A. (2019). Pathogenesis and Consequences of Disordered Sleep in PCOS. Clinical Medicine Insights. Reproductive Health, 13, 1179558119871269. https://doi.org/10.1177/1179558119871269

Shahin, A. Y., & Mohammed, S. A. (2014). Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates—A randomized trial. Gynecological Endocrinology: The Official Journal of the International Society of Gynecological Endocrinology, 30(7), 505–510. https://doi.org/10.3109/09513590.2014.895983

Shamasbi, S. G., Ghanbari-Homayi, S., & Mirghafourvand, M. (2020). The effect of probiotics, prebiotics, and synbiotics on hormonal and inflammatory indices in women with polycystic ovary syndrome: A systematic review and meta-analysis. European Journal of Nutrition, 59(2), 433–450. https://doi.org/10.1007/s00394-019-02033-1

Shishehgar, F., Mirmiran, P., Rahmati, M., Tohidi, M., & Ramezani Tehrani, F. (2019). Does a restricted energy low glycemic index diet have a different effect on overweight women with or without polycystic ovary syndrome? BMC Endocrine Disorders, 19(1), 93. https://doi.org/10.1186/s12902-019-0420-1

Sills, E. S., Perloe, M., Tucker, M. J., Kaplan, C. R., Genton, M. G., & Schattman, G. L. (2001). Diagnostic and treatment characteristics of polycystic ovary syndrome: Descriptive measurements of patient perception and awareness from 657 confidential self-reports. BMC Women’s Health, 1, 3. https://doi.org/10.1186/1472-6874-1-3

Sortino, M. A., Salomone, S., Carruba, M. O., & Drago, F. (2017). Polycystic Ovary Syndrome: Insights into the Therapeutic Approach with Inositols. Frontiers in Pharmacology, 8. https://doi.org/10.3389/fphar.2017.00341

Spinedi, E., & Cardinali, D. P. (2018). The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy. International Journal of Endocrinology, 2018. https://doi.org/10.1155/2018/1349868

Sverrisdóttir, Y. B., Mogren, T., Kataoka, J., Janson, P. O., & Stener-Victorin, E. (2008). Is polycystic ovary syndrome associated with high sympathetic nerve activity and size at birth? American Journal of Physiology - Endocrinology and Metabolism, 294(3), E576–E581. https://doi.org/10.1152/ajpendo.00725.2007

Unfer, V., Carlomagno, G., Rizzo, P., Raffone, E., & Roseff, S. (2011). Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. European Review for Medical and Pharmacological Sciences, 15(4), 452–457.

Unfer, Vittorio, Carlomagno, G., Papaleo, E., Vailati, S., Candiani, M., & Baillargeon, J.-P. (2014). Hyperinsulinemia Alters Myoinositol to d-chiroinositol Ratio in the Follicular Fluid of Patients With PCOS. Reproductive Sciences (Thousand Oaks, Calif.), 21(7), 854–858. https://doi.org/10.1177/1933719113518985

Unfer, Vittorio, Nestler, J. E., Kamenov, Z. A., Prapas, N., & Facchinetti, F. (2016). Effects of Inositol(s) in Women with PCOS: A Systematic Review of Randomized Controlled Trials. International Journal of Endocrinology, 2016. https://doi.org/10.1155/2016/1849162

Unfer, Vittorio, Orrù, B., & Monastra, G. (2016). Inositols: From physiology to rational therapy in gynecological clinical practice. Expert Opinion on Drug Metabolism & Toxicology, 12(10), 1129–1131. https://doi.org/10.1080/17425255.2016.1225039

Varlamov, O. (2017). Western-style diet, sex steroids and metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1863(5), 1147–1155. https://doi.org/10.1016/j.bbadis.2016.05.025

Wulffelé, M. G., Kooy, A., Lehert, P., Bets, D., Ogterop, J. C., Borger van der Burg, B., Donker, A. J. M., & Stehouwer, C. D. A. (2003). Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: A randomized, placebo-controlled trial. Journal of Internal Medicine, 254(5), 455–463. https://doi.org/10.1046/j.1365-2796.2003.01213.x


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