Hi there.

Thanks for your interest in the endothelial glycocalyx. It’s great to know that there are other physiology buffs out there :). Please find key references from my presentation at the 2014 NANP conference listed below. Feel free to contact me with questions as well.  – Camille

Researchers to Follow:

Review of the RAAS & Aldosterone:

Both from the Khan Academy


Overwhelmed? I’ve highlighted the best papers with which to start in purple below. Most of these are free on PubMed. Enjoy :).

  • Ballinger, M. L., Nigro, J., Frontanilla, K. V., Dart, A. M., & Little, P. J. (2004). Regulation of glycosaminoglycan structure and atherogenesis. Cellular and Molecular Life Sciences: CMLS, 61(11), 1296–1306. doi:10.1007/s00018-004-3389-4
  • Blaustein, M. P., Leenen, F. H. H., Chen, L., Golovina, V. A., Hamlyn, J. M., Pallone, T. L., … Wier, W. G. (2012). How NaCl raises blood pressure: a new paradigm for the pathogenesis of salt-dependent hypertension. American Journal of Physiology. Heart and Circulatory Physiology302(5), H1031–1049. doi:10.1152/ajpheart.00899.2011
  • Curry, F.-R. E., & Adamson, R. H. (2010). Vascular permeability modulation at the cell, microvessel, or whole organ level: towards closing gaps in our knowledge. Cardiovascular Research, 87(2), 218–229. doi:10.1093/cvr/cvq115
  • Eskens, B. J., Zuurbier, C. J., van Haare, J., Vink, H., & van Teeffelen, J. W. (2013). Effects of two weeks of metformin treatment on whole-body glycocalyx barrier properties in db/db mice. Cardiovascular Diabetology, 12, 175. doi:10.1186/1475-2840-12-175
  • Florian, J. A., Kosky, J. R., Ainslie, K., Pang, Z., Dull, R. O., & Tarbell, J. M. (2003). Heparan sulfate proteoglycan is a mechanosensor on endothelial cells. Circulation Research93(10), e136–142. doi:10.1161/01.RES.0000101744.47866.D5
  • Golestaneh, N., Klein, C., Valamanesh, F., Suarez, G., Agarwal, M. K., & Mirshahi, M. (2001). Mineralocorticoid receptor-mediated signaling regulates the ion gated sodium channel in vascular endothelial cells and requires an intact cytoskeleton. Biochemical and Biophysical Research Communications280(5), 1300–1306. doi:10.1006/bbrc.2001.4275
  • Holubarsch, C. J. F., Colucci, W. S., Meinertz, T., Gaus, W., & Tendera, M. (2008). The efficacy and safety of Crataegus extract WS® 1442 in patients with heart failure: The SPICE trial. European Journal of Heart Failure, 10(12), 1255–1263. doi:10.1016/j.ejheart.2008.10.004
  • Kusche-Vihrog, K., & Oberleithner, H. (2012). An emerging concept of vascular salt sensitivity. F1000 Biology Reports, 4. doi:10.3410/B4-20
  • Lemkes, B. A., Hermanides, J., Devries, J. H., Holleman, F., Meijers, J. C. M., & Hoekstra, J. B. L. (2010). Hyperglycemia: a prothrombotic factor? Journal of Thrombosis and Haemostasis: JTH, 8(8), 1663–1669. doi:10.1111/j.1538-7836.2010.03910.x
  • Nguyen Dinh Cat, A., & Jaisser, F. (2012). Extrarenal effects of aldosterone. Current Opinion in Nephrology and Hypertension21(2), 147–156. doi:10.1097/MNH.0b013e32834fb25b
  • Oberleithner, H. (2012). Two barriers for sodium in vascular endothelium? Annals of Medicine, 44 Suppl 1, S143–148. doi:10.3109/07853890.2011.653397
  • Oberleithner, H., Peters, W., Kusche-Vihrog, K., Korte, S., Schillers, H., Kliche, K., & Oberleithner, K. (2011). Salt overload damages the glycocalyx sodium barrier of vascular endothelium. Pflugers Archiv, 462(4), 519–528. doi:10.1007/s00424-011-0999-1
  • Peters, W., Drueppel, V., Kusche-Vihrog, K., Schubert, C., & Oberleithner, H. (2012). Nanomechanics and sodium permeability of endothelial surface layer modulated by hawthorn extract WS 1442. PloS One, 7(1), e29972. doi:10.1371/journal.pone.0029972
  • Rana, J. S., Nieuwdorp, M., Jukema, J. W., & Kastelein, J. J. P. (2007). Cardiovascular metabolic syndrome – an interplay of, obesity, inflammation, diabetes and coronary heart disease. Diabetes, Obesity & Metabolism, 9(3), 218–232. doi:10.1111/j.1463-1326.2006.00594.x
  • Reitsma, S., Oude Egbrink, M. G. A., Heijnen, V. V. T., Megens, R. T. A., Engels, W., Vink, H., … van Zandvoort, M. A. M. J. (2011). Endothelial glycocalyx thickness and platelet-vessel wall interactions during atherogenesis. Thrombosis and Haemostasis, 106(5), 939–946. doi:10.1160/TH11-02-0133
  • Reitsma, S., Slaaf, D. W., Vink, H., van Zandvoort, M. A. M. J., & oude Egbrink, M. G. A. (2007). The endothelial glycocalyx: composition, functions, and visualization. Pflugers Archiv, 454(3), 345–359. doi:10.1007/s00424-007-0212-8
  • Van den Berg, B. M., Spaan, J. A. E., Rolf, T. M., & Vink, H. (2006). Atherogenic region and diet diminish glycocalyx dimension and increase intima-to-media ratios at murine carotid artery bifurcation. American Journal of Physiology. Heart and Circulatory Physiology, 290(2), H915–920. doi:10.1152/ajpheart.00051.2005
  • Vogl-Willis, C. A., & Edwards, I. J. (2004). High-glucose-induced structural changes in the heparan sulfate proteoglycan, perlecan, of cultured human aortic endothelial cells. Biochimica et Biophysica Acta, 1672(1), 36–45. doi:10.1016/j.bbagen.2004.02.005

~ More to Explore ~

Sign up for weekly Practitioner Notes from Camille.

Tips, resources, & encouragement for herbalists & nutritionists, delivered to your inbox most Thursdays.